Dr. Balázs Károly Libisch - MATE Research
Overview
Dr. Balázs Libisch's primary research interests encompass the epidemiology of acquired antibiotic resistance determinants in pathogenic and commensal bacteria from a One Health perspective. He aims to counteract the spread of antibiotic resistance by exploring its reservoirs and methods of dissemination, as well as by developing potential alternatives to antibiotics. Approaches to these goals also entail studies on the gut microbiota of domestic and wild animals, along with an investigation into the role of environmental factors in the complex challenges arising in agriculture.He has taken part in several international collaborations with European partner institutes or universities in the fields of microbiology and biotechnology.
Research keywords:
Publications
Acquired antibiotic resistance determinants in pathogenic and commensal bacteria
Identification of PER-1 extended-spectrum β-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia
Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues
Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Sus scrofa) and Common Carp (Cyprinus carpio) Intestinal Samples by Metagenomics Analyses in Hungary
Molecular epidemiology of antibiotic-resistant bacteria
Identification of PER-1 extended-spectrum β-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia
Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues
Analyses of the gut microbiota in wild and domestic animals
Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues
Characterisation of microorganisms with biotechnological importance or probiotic potential
The most relevant publications are avaliable through the author's Scopus profile
Projects
DRESP2 - Role of Mobile Genetic Elements in the Spread of Antimicrobial Drug Resistance
Mobile DNA provides a major contribution to the spread of antimicrobial resistance, by recruiting new resistance genes in bacterial pathogens and facilitating their horizontal spread. The DRESP2 project aimed at investigating the nature of the mobile elements and their transfer mechanisms, focusing on a few major families of genetic elements that carry a number of important and emerging resistance determinants in pathogenic bacteria.
https://cordis.europa.eu/project/id/18705/reporting
SOILCAM - Soil contamination: advanced integrated characterisation and time-lapse monitoring
The overall objective of the project was to determine necessary basis for designing an optimal combination of invasive and non-invasive methods for monitoring degradable contaminants in spatially variable soil systems. To achieve that, SOILCAM combined advanced conventional soil monitoring techniques with geophysical approaches. These were interpreted individually and combined. SOILCAM activities were centred on two European field sites faced with contamination issues: Trecate in Northern Italy (light oil) and Gardermoen (de-icing chemicals) in Southern Norway. Geophysical time-lapse measurements were combined with point data collection and microbiological methods.
https://cordis.europa.eu/project/id/212663/reporting
Agribiotechnology and precision breeding for food security National Laboratory
The main objective of the National Laboratory is to give scientifically based responses to complex challenges emerging in agriculture. The project integrates the main components of the agroecosystem and the micro-plant-animal triangle assigning food security of „One Health View” set up by WHO as a common goal.
GINOP-2.3.2-15-2016-00046
Estimation of human exposure to the mycotoxin fumonisin B1, determination of toxin-induced oxidative stress, cell damage and metabolic changes using in vitro and animal experimental models
The aim of the project was to assess the risk of fumonisin mycotoxin, one of the most common contaminants of corn. Fumonisin B1 (FB1) is also one of the most common mycotoxins in Hungary, which occurs besides corn in other feed and food materials. In the course of the research, the toxin's less known mechanism of action at the cellular level was also investigated. The primary goal was to assess the harmful effects caused by FB1. According to the results obtained, fumonisin changed the composition of the gut microbiota in domestic pigs.
https://palyazatok.uni-mate.hu/web/mate-p%C3%A1ly%C3%A1zatok/GINOP-2.3.2-15-2016-00046
NeoGiant - The power of grape extracts
Antimicrobial resistance occurs also naturally, however, the misuse or overuse of antibiotics is accelerating its emergence and spread. The NeoGiant project is based on the use of biomass sources (white grape marc) that can provide cost-effective and green solutions to obtain functional ingredients in sustainable circular economy production systems as potential alternatives to antibiotics.
